Nybo, Rasmussen & Sawka 2014, Performance in the heat: physiological factors of hyperthermia-induced fatigue

Review (Comprehensive Physiology 4(2):657–689). Exercise in the heat imposes a thermoregulatory burden that drives cardiovascular strain, raises ventilation, alters muscle metabolism and impairs central drive. Rising core temperature provokes central fatigue (reduced ability to sustain maximal muscle activation) and contributes to anticipatory reductions in self-selected pace; the factors interact contextually rather than one cause dominating. Strong as a mechanistic review.